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Effect of gastric fluid on adsorption and desorption of endocrine disrupting chemicals on microplastics

《环境科学与工程前沿（英文）》 2022年 第16卷 第8期 doi: 10.1007/s11783-022-1525-8

摘要：

• Effect of gastric fluid on EDCs adsorption-desorption to microplastics was evaluated.

关键词： Microplastics     Gastric fluid     Endocrine-disrupting chemicals     Adsorption     Desorption    

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Removal of endocrine disrupting chemicals from water through urethane functionalization of microfiltration

《环境科学与工程前沿（英文）》 2023年 第18卷 第4期 doi: 10.1007/s11783-024-1805-6

摘要：

● Urethane functionalities created on PES membranes via electron beam irradiation.

关键词： Surface functionalization     Electron beam irradiation     Microfiltration     Endocrine disrupting chemicals    

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Application of permanganate in the oxidation of micropollutants: a mini review

Xiaohong GUAN, Di HE, Jun MA, Guanghao CHEN

《环境科学与工程前沿（英文）》 2010年 第4卷 第4期   页码 405-413 doi: 10.1007/s11783-010-0252-8

摘要： As a green oxidant, permanganate has received considerable attention for the removal of micropollutants in drinking water treatment. To provide a better understanding of the oxidation of organic micropollutants with permanganate, the oxidation kinetics of 32 micropollutants were compiled. The pollutants include algal toxins, endocrine disrupting chemicals (EDCs), and pharmaceuticals. The oxidation kinetics of micropollutants by permanganate were found to be first order with respect to both contaminant and permanganate concentrations from which second-order rate constants ( ″) were obtained. Permanganate oxidized the heterocyclic aromatics with vinyl moiety (i.e., microcystins, carbamazepine, and dichlorvos) by the addition of double bonds. For the polycyclic aromatic hydrocarbons (PAHs) with alkyl groups, permanganate attacked the benzylic C-H through abstraction of hydrogen. The mechanism for the oxidation of phenolic EDCs by permanganate was a single electron transfer and aromatic ring cleavage. The presence of background matrices could enhance the oxidation of some phenolic EDCs by permanganate, including phenol, chlorinated phenols, bisphenol A, and trichlosan. The toxicity of dichlorvos solution increased after permanganate oxidation, and the estrogenic activity of bisphnol A/estrone increased significantly at the beginning of permanganate oxidation. Therefore, the toxicity of degradation products or intermediates should be determined in the permanganate oxidation processes to better evaluate the applicability of permanganate. The influence of background ions on the permanganate oxidation process is far from clear and should be elucidated in the future studies to better predict the performance of permanganate oxidation of micropollutants. Moreover, methods should be employed to catalyze the permanganate oxidation process to achieve better removal of micropollutants.

关键词： pharmaceuticals     endocrine disrupting chemicals (EDCs)     algal toxins     permanganate     oxidation    

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Determination and occurrence of endocrine disrupting compounds, pharmaceuticals and personal care products

Yong YU,Laosheng WU

《环境科学与工程前沿（英文）》 2015年 第9卷 第3期   页码 475-481 doi: 10.1007/s11783-014-0640-6

摘要： Endocrine disrupting compounds (EDCs), pharmaceuticals and personal care products (PPCPs) have attracted much attention due to widespread contamination in aquatic environment. In this study, we determined 13 EDCs and PPCPs in fish blood, bile and muscle by using gas chromatography-mass spectrometry (GC-MS). The limits of quantitation (LOQ) were in the ranges of 0.23–2.54, 0.22–2.36 ng·mL , and 0.24–2.57 ng·g dry weight (dw) for fish blood, bile and muscle, respectively. Recoveries of target compounds spiked into sample matrices and passed through the entire analytical procedure ranged from 65% to 95%, from 60% to 92% and from 62% to 91% for blood, bile and muscle, respectively. The methods were applied to the analysis of fish from a lake in California. Target compounds were relatively low in bile, and only bisphenol A (BPA) and diclofenac were measurable near the LOQ. Seven of 13 compounds were detected in blood, with total concentrations up to 39 ng·mL . Only BPA was frequently found in muscle, with mean concentration of 7.26 ng·g dw. The estimated daily intake of BPA through fish consumption for U.S. resident was significantly lower than the tolerable daily intake recommended by the European Food Safety Authority. This study showed that the exposure to the bisphenol A from fish diet is unlikely to pose a health risk.

关键词： endocrine disrupting compounds (EDCs)     pharmaceuticals and personal care products (PPCPs)     fish     bisphenol A (BPA)     risk assessment    

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Occurrence of estrogenic endocrine disrupting chemicals concern in sewage plant effluent

Yan SUN, Huang HUANG, Ying SUN, Chao WANG, Xiaolei SHI, Hongying HU, Takashi KAMEYA, Koichi FUJIE

《环境科学与工程前沿（英文）》 2014年 第8卷 第1期   页码 18-26 doi: 10.1007/s11783-013-0573-5

摘要： The purpose of this study was to give a worldwide overview of the concentrations of typical estrogenic endocrine disrupting chemicals (EDCs) in the effluent of sewage plants and then compare the concentration distribution of the estrogenic EDCs in ten countries based on the survey data of the estrogenic EDCs research. The concentrations of three main categories (totally eight kinds) of estrogenic EDCs including steroidal estrogens (estrone (E1), estradiol (E2), estriol (E3) and 17α-ethynylestradiol (EE2)), phenolic compounds (nonylphenol (NP) and bisphenol A (BPA)) and phthalate esters (dibutyl phthalate (DBP) and dibutyl phthalate (2-ethylhexyl) phthalate (DEHP)) in the effluents of sewage plants reported in major international journals over the past decade were collected. The statistics showed that the concentration distributions of eight kinds of EDCs were in the range of ng·L to μg·L . The concentrations of steroidal estrogens mainly ranged within 50.00 ng·L , and the median concentrations of E1, E2, E3 and EE2 were 11.00, 3.68, 4.90 and 1.00 ng·L , respectively. Phenolic compounds and phthalate esters were found at μg·L level (some individual values were at the high level of 40.00 μg·L ). The median concentrations of BPA, NP, DBP and DEHP were 0.06, 0.55, 0.07 and 0.88 μg·L , respectively. The concentrations of phenolic compounds and phthalate esters in the effluents were higher than that of steroids estrogens. The analysis of the concentration in various ten countries showed that steroids estrogens, phenolic compounds and phthalate esters in sewage plant effluents were detected with high concentration in Canada, Spain and China, respectively.

关键词： estrogenic endocrine disrupting chemicals     concentration distribution     sewage plant    

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nanochannels of MOF thin-film nanocomposite nanofiltration membranes for efficient removal of hydrophobic endocrinedisrupting compounds

《环境科学与工程前沿（英文）》 2022年 第16卷 第4期 doi: 10.1007/s11783-021-1474-7

摘要：

• PA layer properties tune the primary nanochannels in MIL-101(Cr) TFN NF membranes.

关键词： Porous metal organic framework     Thin-film nanocomposite membrane     Primary selective nanochannels     Nanofiltration     Endocrine disrupting compounds    

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In vitro agonistic and antagonistic endocrine disrupting effects of organic extracts from waste water

Kaifeng RAO, Na LI, Mei MA, Zijian WANG

《环境科学与工程前沿（英文）》 2014年 第8卷 第1期   页码 69-78 doi: 10.1007/s11783-013-0502-7

摘要： Effluents from wastewater treatment plant (WWTP) have been reported to have a broad spectrum of endocrine disrupting compounds (EDCs). The majority of studies have focused on the occurrence of estrogenic activity, while ignoring nuclear hormone receptors (NRs) pathways. In the present study, a battery of in vitro yeast bioassays and a cell bioassay, including antagonistic and agonistic effects on estrogen receptor (ER), androgen receptor (AR), progesterone receptor (PR), estrogen-related receptor (ERR) and aryl hydrocarbon receptor (AHR), were conducted to evaluate the removal efficiencies of EDCs by different treatment processes of a WWTP located in Beijing. Estrogenic, anti-estrogenic, anti- androgenic, anti-progesteronic, anti-ERR and the activation of AHR activities were detected in samples from all treatment processes and the receiving water. The concentration of estrogenic contaminants with estradiol (E ) equivalent concentrations ranged from 0.82 × 10 to 3.54 × 10 g E -EQ·L . The concentration of anti-estrogenic contaminants with 4-hydroxytamoxifen (4-OHT) equivalent concentrations ranged from 1.24 × 10 to 2.36 × 10 g 4-OHT-EQ·L . The concentration of anti-androgenic contaminants ranged from 2.21 × 10 to 3.52 × 10 g flutamide-EQ·L . The concentration of anti-progesteronic contaminants ranged from 3.15 × 10 to 2.71 × 10 g RU486-EQ·L . The concentration of anti-ERR contaminants ranged from 7.09 × 10 to 6.50 × 10 g 4-OHT-EQ·L . The concentration of AHR activators ranged from 1.7 × 10 to 3.4 × 10 g TCDD-EQ·L . These processes including secondary clarifier, coagulation, as well as coal and sand filtration could eliminated 67.2% of estrogenic contaminants, 47.0% of anti-estrogenic contaminants, 98.3% of anti-androgenic contaminants, 88.4% of anti-progesteronic contaminants, 65.4% of anti-ERR contaminants and 46.9% of AHR activators. WWTP effluents contain multiple receptor disruptors may have very complex adverse effects on exposed organisms.

关键词： waste water     in vitro     recombinant yeast assay     ethoxyresorufin-O-deethylase (EROD)     receptor     endocrine    

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食品中环境新污染物危害管控研究

陈玲 ,杨潇 ,张琳钰 ,胡海冬 ,王瑾丰 ,吴兵 ,任洪强

《中国工程科学》 2022年 第24卷 第6期   页码 99-106 doi: 10.15302/J-SSCAE-2022.07.003

摘要： 本文梳理了蔬菜、水果、谷物、肉 类、水产类、蛋奶等主要食品中抗生素、内分泌干扰物（EDCs）、全氟化合物（PFCs）、微塑料（MPs）四大类新污染物的赋 存现状、危害特征及来源。研究发现，喹诺酮类抗生素在水产品、蔬菜、牛奶等食品中的检出率较高，主要来源于农兽药的使 用；EDCs中的双酚A在罐头食品、水产品中的检出率较高，壬基酚多检出于水产品中，两者主要来源于食品包装析出；PFCs

关键词： 食品安全；环境新污染物；抗生素；全氟化合物；内分泌干扰物；微塑料    

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Selective preparation for biofuels and high value chemicals based on biochar catalysts

《能源前沿（英文）》 2023年 第17卷 第5期   页码 635-653 doi: 10.1007/s11708-023-0878-4

摘要： The reuse of biomass wastes is crucial toward today’s energy and environmental crisis, among which, biomass-based biochar as catalysts for biofuel and high value chemical production is one of the most clean and economical solutions. In this paper, the recent advances in biofuels and high chemicals for selective production based on biochar catalysts from different biomass wastes are critically summarized. The topics mainly include the modification of biochar catalysts, the preparation of energy products, and the mechanisms of other high-value products. Suitable biochar catalysts can enhance the yield of biofuels and higher-value chemicals. Especially, the feedstock and reaction conditions of biochar catalyst, which affect the efficiency of energy products, have been the focus of recent attentions. Mechanism studies based on biochar catalysts will be helpful to the controlled products. Therefore, the design and advancement of the biochar catalyst based on mechanism research will be beneficial to increase biofuels and the conversion efficiency of chemicals into biomass. The advanced design of biochar catalysts and optimization of operational conditions based on the biomass properties are vital for the selective production of high-value chemicals and biofuels. This paper identifies the latest preparation for energy products and other high-value chemicals based on biochar catalysts progresses and offers insights into improving the yield of high selectivity for products as well as the high recyclability and low toxicity to the environment in future applications.

关键词： biomass     biochar catalysts     biofuels     high chemicals    

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Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

《医学前沿（英文）》 2021年 第15卷 第2期   页码 208-220 doi: 10.1007/s11684-020-0795-4

摘要： New targeted therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2 advanced breast cancer (ABC). We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR /HER2 ABC. PUBMED and EMBASE databases were searched for eligible trials. Hazard ratios (HRs) for progression-free survival (PFS), odds ratios (ORs) for objective response rate (ORR), clinical benefit rate (CBR), and toxicity were meta-analyzed. Twenty-six studies with data on 10 347 patients were included and pooled. The addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR= 0.547, <0.001), overall survival (pooled HR= 0.755, <0.001), and tumor response rates (ORR, pooled OR= 1.478, <0.001; CBR, pooled OR= 1.201, <0.001) with manageable toxicities (pooled OR= 3.280, <0.001). The mammalian targets of rapamycin inhibitors and exemestane were not clinically beneficial for this pooled population including ET-naïve and ET-resistant patients. Moderate improvement in PFS (pooled HR= 0.686, <0.001) yet pronounced toxicities (pooled OR= 2.154, <0.001) were noted in the combination of phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors with fulvestrant. Future studies are warranted to optimize the population and the dosing sequence of these available options.

关键词： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials     meta-analysis     targeted therapy    

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Power-to-chemicals: sustainable liquefaction of food waste with plasma-electrolysis

《化学科学与工程前沿（英文）》 2023年 第17卷 第5期   页码 594-605 doi: 10.1007/s11705-022-2255-y

摘要： The increasing amount of food waste from various industrial, agricultural, and household sources is an environmental burden if managed inappropriately. Numerous waste management approaches have been developed for the disposal of food waste, but still suffer from either high cost, production of toxic by-products, or secondary environmental pollutions. Herein, we report a new and sustainable plasma electrolysis biorefinery route for the rapid and efficient liquefaction of food waste. During the plasma electrolysis process, only the solvent is added to liquefy the waste, and anions in the waste can contribute to catalyzing the biowaste conversion. While liquefying the waste, the highly reactive species produced in the plasma electrolysis process can efficiently reduce the content of O, N, and Cl in the liquefied products and oxidize most of the metals into solid residues. Especially, the removal rate of Na and K elements was greater than 81%, which is significantly higher than using the traditional oil bath liquefaction, resulting in a relatively high-quality biocrude oil with a high heating value of 25.86 MJ·kg–1. Overall, this proposed strategy may provide a new sustainable and eco-friendly avenue for the power-to-chemicals valorization of food waste under benign conditions.

关键词： plasma electrolysis     food waste     liquefaction     resource recovery    

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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

《医学前沿（英文）》 doi: 10.1007/s11684-023-1003-0

摘要： Lipin proteins including Lipin 1–3 act as transcriptional co-activators and phosphatidic acid phosphohydrolase enzymes, which play crucial roles in lipid metabolism. However, little is known about the function of Lipin3 in triglyceride (TG) metabolism. Here, we identified a novel mutation (NM_001301860: p.1835A>T/p.D612V) of Lipin3 in a large family with hypertriglyceridemia (HTG) and obesity through whole-exome sequencing and Sanger sequencing. Functional studies revealed that the novel variant altered the half-life and stability of the Lipin3 protein. Hence, we generated Lipin3 heterozygous knockout (Lipin3-heKO) mice and cultured primary hepatocytes to explore the pathophysiological roles of Lipin3 in TG metabolism. We found that Lipin3-heKO mice exhibited obvious obesity, HTG, and non-alcoholic fatty liver disorder. Mechanistic study demonstrated that the haploinsufficiency of Lipin3 in primary hepatocytes may induce the overexpression and abnormal distribution of Lipin1 in cytosol and nucleoplasm. The increased expression of Lipin1 in cytosol may contribute to TG anabolism, and the decreased Lipin1 in nucleoplasm can reduce PGC1α, further leading to mitochondrial dysfunction and reduced TG catabolism. Our study suggested that Lipin3 was a novel disease-causing gene inducing obesity and HTG. We also established a relationship between Lipin3 and mitochondrial dysfunction.

关键词： Lipin3     Lipin1     hypertriglyceridemia     obesity     mitochondrial dysfunction    

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Valorisation of protein waste: An enzymatic approach to make commodity chemicals? ?

Madura B. A. Kumar, Yuan Gao, Wei Shen, Lizhong He

《化学科学与工程前沿（英文）》 2015年 第9卷 第3期   页码 295-307 doi: 10.1007/s11705-015-1532-4

摘要： Protein-rich waste is an abundantly available resource that is currently used mainly as animal feed and fertilizers. Valorisation of protein waste to higher value products, particularly commodity chemicals such as precursors for polymers, has attracted significant research efforts. Enzyme-based approaches, being environmentally-friendly compared to their chemical counterparts, promise sustainable processes for conversion of protein waste to valuable chemicals. This review provides a general overview on valorisation of protein waste and then further summarises the use of enzymes in different stages of the valorisation process—protein extraction and hydrolysis, separation of individual amino acids and their ultimate conversion into chemicals. Case studies of enzymatic conversion are presented for different amino acids including glutamic acid, lysine, phenylalanine, tyrosine, arginine and aspartic acid. The review compares the different enzyme reactors and operation modes for amino acid conversion. The emerging opportunities and challenges in the field are discussed: engineering powerful enzymes and integrating innovative processes for industrial application at a low cost.

关键词： amino acids     protein waste     reactor     conversion     commodity chemicals     enzymes    

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Degradation of endocrine disruptor bisphenol A in drinking water by ozone oxidation

XU Bin, GAO Naiyun, RUI Min, WANG Hong, WU Haihui

《环境科学与工程前沿（英文）》 2007年 第1卷 第3期   页码 350-356 doi: 10.1007/s11783-007-0060-y

摘要： The ozone oxidation of endocrine disruptor bisphenol A in drinking water was investigated. A stainless completely mixed reactor was employed to carry out the degradation experiments by means of a batch model. With an initial concentration of 11.0 mg/L, the removal efficiencies of BPA (bisphenol A) could be measured up to 70%, 82%, and 90% when the dosages of ozone were 1, 1.5, and 2 mg/L, respectively. The impacts on BPA degradation under the conditions of different ozone dosages, water background values, BPA initial concentrations, and ozone adding time were analyzed. The results showed that ozone dosage plays a dominant role during the process of BPA degradation, while the impact of the contact time could be ignored. UV wavelength scanning was used to confirm that the by-products were produced, which could be absorbed at UV254. The value of UV254 was observed to have changed during the ozonation process. Based on the change of UV254, it could be concluded that BPA is not completely degraded at low ozone dosage, while shorter adding time of total ozone dosage, high ozone dosage, and improvement of dissolved ozone concentration greatly contribute to the extent of BPA degradation. The effects of applied HO dose in ozone oxidation of BPA were also examined in this study. The O-HO processes proved to have similar effects on the degradation of BPA by ozone oxidation.

关键词： BPA     scanning     reactor     process     O-HO    

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Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in

LIU Cao,XU Yiping,MA Mei,HUANG Bingbin,WU Jingdong,MENG Qingyi,WANG Zijian,GEARHEART Robert Alan

《环境科学与工程前沿（英文）》 2014年 第8卷 第3期   页码 433-440 doi: 10.1007/s11783-013-0594-0

摘要： Study on effective disposal and utilization of sewage sludge has recently been the target of growing interest in China. However, potential risks are associated with the use of sludge due to its contamination with toxic organics, heavy metals and pathogenic microorganisms. In this study, a screening assessment was conducted on sewage sludge samples collected from 17 different sewage treatment plants in Beijing, based on a batch of in vitro bioassays, including a set of recombinant gene yeast assays for endocrine disruption, and an ethoxy resorufin-O-deethylase (EROD) assay using H4IIE cells for aryl hydrocarbon receptor (Ah-R) agonistic activities. Our results suggested that moderate levels of estrogen receptor agonistic activities (0.9 ng E2·g to 6.8 ng E2·g , dw), but relative higher androgen receptor antagonistic activities (nd to 45%), progestin receptor antagonistic activities (nd to 80%) and Ah-R agonistic activities (1390 to 6740 pg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)·g , dw) were found in sewage sludge samples. However, there were no significant correlations between the toxic effects of sewage sludge and the sewage treatment processes. In addition, the 17β-estradiol (E2) equivalent quantity (EEQ) level of the sewage sludge was increased after the composting treatment, whereas the 2,3,7,8-tetrachlorodibenzo- -dioxin toxic equivalent quantity (TEQ) level of sewage sludge composted was much lower than that of sewage sludge.

关键词： sewage sludge     in vitro bioassay     endocrine disruption     dioxin-like effect    

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标题 作者 时间 类型 操作

Effect of gastric fluid on adsorption and desorption of endocrine disrupting chemicals on microplastics

期刊论文

Removal of endocrine disrupting chemicals from water through urethane functionalization of microfiltration

期刊论文

Application of permanganate in the oxidation of micropollutants: a mini review

Xiaohong GUAN, Di HE, Jun MA, Guanghao CHEN

期刊论文

Determination and occurrence of endocrine disrupting compounds, pharmaceuticals and personal care products

Yong YU,Laosheng WU

期刊论文

Occurrence of estrogenic endocrine disrupting chemicals concern in sewage plant effluent

Yan SUN, Huang HUANG, Ying SUN, Chao WANG, Xiaolei SHI, Hongying HU, Takashi KAMEYA, Koichi FUJIE

期刊论文

nanochannels of MOF thin-film nanocomposite nanofiltration membranes for efficient removal of hydrophobic endocrinedisrupting compounds

期刊论文

In vitro agonistic and antagonistic endocrine disrupting effects of organic extracts from waste water

Kaifeng RAO, Na LI, Mei MA, Zijian WANG

期刊论文

食品中环境新污染物危害管控研究

陈玲 ,杨潇 ,张琳钰 ,胡海冬 ,王瑾丰 ,吴兵 ,任洪强

期刊论文

Selective preparation for biofuels and high value chemicals based on biochar catalysts

期刊论文

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

期刊论文

Power-to-chemicals: sustainable liquefaction of food waste with plasma-electrolysis

期刊论文

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

期刊论文

Valorisation of protein waste: An enzymatic approach to make commodity chemicals? ?

Madura B. A. Kumar, Yuan Gao, Wei Shen, Lizhong He

期刊论文

Degradation of endocrine disruptor bisphenol A in drinking water by ozone oxidation

XU Bin, GAO Naiyun, RUI Min, WANG Hong, WU Haihui

期刊论文

Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in

LIU Cao,XU Yiping,MA Mei,HUANG Bingbin,WU Jingdong,MENG Qingyi,WANG Zijian,GEARHEART Robert Alan

期刊论文